CAR-T cells sent autoimmune diseases into remission. There’s hope that the therapy is scalable. And, scientists used decades of yellow-bellied marmot research to find a way to measure how adverse events affect wild animals’ survival. Show Promise For Autoimmune Diseases For decades, immunologists have explored CAR-T cell therapy as an effective tool to fight blood cancer. Increasingly, CAR-T cells are being explored as a potential silver bullet for , like lupus—which currently have no cure.

Thus far, CAR-T cell therapy has largely used CRISPR-modified immune cells from a person to treat that person’s own diseases. But new research from China has made a huge step forward for this treatment: Researchers were successful in from one person to treat another person’s systemic sclerosis, an autoimmune condition that causes atypical growth of connective tissues.If donor CAR-T cell therapy does indeed work, as posited in this paper, it could mean the therapy is more scalable than it would be otherwise. Joining Ira to talk about this study and its potential impact is Daniel Baker, PhD student in the immunology lab of Dr. Carl June at the University of Pennsylvania.

It’s well-established in psychology that if you experience trauma as a child, chances are it’ll impact your physical and mental health as an adult, and could even affect your economic status. In academic terms, this is called. And psychologists have developed a scoring system for measuring the cumulative effect of adverse childhood experiences, which can include abuse and household dysfunction, and it can help predict health risks later in life.So we can specifically measure that in humans. If you’ve adopted a dog that’s had a turbulent past, you know that that can result in reclusive or skittish behavior as an adult. But there hasn’t been a good way to measure it in wild animals.

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